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Abstract #2552

­­­Expanding the limits of cardiovascular MR: amyloid detection in the liver and spleen

Michele Boldrini1,2, Andrea Baggiano1, Ana Martinez-Naharro1, Tushar Kotecha1, Tamer Rezk3, Daniel Knight1, James Moon4, Peter Kellman5, Julian Gillmore3, Philip Hawkins3, and Marianna Fontana1

1CMR department, National Amyloidosis Center, UCL Royal Free Hospital, London, United Kingdom, 2Internal Medicine, Università degli Studi di Pavia, Pavia, Italy, 3National Amyloidosis Center, UCL Royal Free Hospital, London, United Kingdom, 4Barts Health - Barts Heart Centre, London, United Kingdom, 5National Institute of Health, Washington, MD, United States

In this study we evaluated the utility of bolus-only ECV maps in extra-cardiac AL amyloidosis by comparing it with SAP scintigraphy findings in liver and spleen. These two techniques where performed in a large prospective cohort of patients with suspected systemic AL amyloidosis and where compared in terms of (1) diagnostic accuracy in liver and spleen amiloidosis; (2) quantification of the liver and spleen amyloid deposits. This was done using a standard acquisition for cardiac studies, with no extra image acquisition or optimization for hypochondriac regions.

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