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Abstract #2562

A comparison of biexponetial fitting and spectral modelling methods for T2 mapping of prostate cancer

Dominic Carlin1,2, Matthew R Orton1,2, Veronica A Morgan1,2, David J Collins1,2, and Nandita M deSouza1,2

1CRUK Imaging Centre, Institute of Cancer Research, London, United Kingdom, 2MRI Unit, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom

Spectral modelling and model fitting were compared for quantitative T2 mapping of the prostate. 32-echo data were acquired from 11 patients with biopsy-proven prostate cancer at 3T. There was excellent correlation between the two approaches for estimates of T2-short, T2-long and luminal water fraction (r=0.96, 0.71, 0.94 respectively). Luminal water fractions were significantly higher in normal peripheral and transition zones using the model fitting approach (P = 0.04 and <0.01 respectively), but were comparable in tumor. The larger quantitative difference between tumour and normal tissue could mean model fitting is superior for qualitative assessment in prostate cancer.

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