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Abstract #2561

Multi-parametric MRI evaluation of prostate cancer volume: correlation with whole mount pathology

Chongpeng Sun1,2, Aritrick Chatterjee1, Ambereen Yousuf1, Tatiana Antic3, Scott Eggener4, Gregory Karczmar1, and Aytekin Oto1

1Department of Radiology, University of Chicago, Chicago, IL, United States, 2Department of Radiology, Guangzhou Medical University, Guangzhou, China, 3Department of Pathology, University of Chicago, Chicago, IL, United States, 4Department of Urology, University of Chicago, Chicago, IL, United States

This study compared prostate cancer volume determined on different multi-parametric MRI sequences: T2W imaging, ADC map and DCE-MRI with whole mount pathology in 17 patients. Tumor volumes were measured on T2W images, ADC maps and DCE-MRI by 2 radiologists and compared with reference standard volume measured from pathology. While lesion volume estimated using mpMRI sequences showed good correlation with pathology, T2W and ADC significantly underestimated, whereas DCE-MRI showed no significant difference. Therefore, DCE-MRI is the most effective sequence for estimating PCa volume with the highest accuracy compared to T2W-imaging and ADC maps and has similar good correlation and precision.

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