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Abstract #2594

Assessment of Treatment Outcome in Chronic Hepatitis C Virus Infected Patients with Liver Stiffness Measured by Magnetic Resonance Elastography

Stephan Rodrigo Marticorena Garcia1, Heiko Tzschätzsch1, Christian Althoff1, Christian Burkhardt1, Michael Dürr2, Fabian Halleck2, Klemens Budde2, Korinna Jöhrens3, Bernd Hamm1, Jürgen Braun4, Thomas Fischer1, Ingolf Sack1, and Jing Guo1

1Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Nephrology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 4Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany

High-resolution stiffness maps of the liver and kidney transplant (KTx) were generated after direct-acting antiviral therapy using multifrequency magnetic resonance elastography (MRE) and tomoelastography data processing in KTx recipients with chronic hepatitis C infection. Changes in liver stiffness after viral clearance were related to the immediate reduction in the inflammatory response in the early period and were stable until one year after end of treatment. MRE promises to be an early predictor for therapeutic success in HCV treatment.

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