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Abstract #2595

Impact of Motion-Encoding Gradient (MEG) Direction, Slice Position and Slice Orientation on the estimation of Liver Stiffness using Magnetic Resonance Elastography (MRE) in clinical patients

Jiming Zhang1, Claudio Arena1, Debra Dees1, Melissa Andrews1, Afis Ajala2, and Raja Muthupillai1

1Diagnostic and Interventional Radiology, Baylor St Luke's Medical Center, Houston, TX, United States, 2Physics and Texas Center for Superconductivity, University of Houston, Houston, TX, United States

As an extension of our previous work done in healthy subjects, we evaluate the impact of the direction of motion-encoding gradient (MEG), slice orientation, and coverage on the estimation of LS in 99 clinical patients referred for MRE. The results from the study show that: (a) liver stiffness (LS) measured with MEG superimposed over RL and AP directions was higher than that of LS measured with MEG in the FH direction; (b) Slight variations in the angulation of the transverse slice has negligible impact on LS estimates; and (c) The percentage area of the liver in which LS can be confidently measured (confidence map area) can have substantial variations (independent of direction of MEG) between slices and therefore, it may be beneficial to acquire more than one slice in a clinical setting.

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