Abstract #2596

Comparison of the QIBA MRE ROI-drawing method to a method standardized by tracing liver parenchyma boundaries

Walter C Henderson¹, Alexandra N Schlein¹, Jonathan C Hooker¹, Yesenia Covarrubias¹, Tanya Wolfson², Adrija Mamidipalli¹, Jennifer Y Cui¹, Yingzhen Zhang¹, Ethan Z Sy¹, Nikolaus M Szeverenyi¹, Rohit Loomba³, and Claude B Sirlin¹

¹Liver Imaging Group, Department of Radiology, UC San Diego, La Jolla, CA, United States, ²Computational and Applied Statistics Laboratory, UC San Diego, La Jolla, CA, United States, ³NAFLD Research Clinic, Division of Gastroenterology, Department of Medicine, UC San Diego, La Jolla, CA, United States

While the Quantitative Imaging Biomarker Alliance (QIBA) draft recommendations on ROI placement in 2D MRE image analysis prescribe that only linear waves and parenchyma at least 1 cm from the liver edge be included, another abstract submitted to this meeting (Mamidipalli et al.) has found that analysts with equivalent experience and skill level draw significantly different ROIs when using these guidelines. This study compares the QIBA method of ROI placement to a method that is more standardized and inclusive, and compares the agreement and bias between each method on 2D MRE liver stiffness measurements.

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