Non-invasive estimation of liver iron concentration (LIC) by R2-MRI is often used for detection, grading and treatment monitoring in patients with suspected or known iron overload. The only current R2-MRI LIC estimation method with regulatory clearance is FerriScan®, a proprietary analysis for biexponential R2-relaxometry. We implemented a nonproprietary biexponential R2-relaxometry using a "dictionary-search" algorithm, to reproduce the FerriScan® results. In 38 patients with known or suspected iron overload, we demonstrated excellent reproducibility (by linearity and absolute agreement) in R2 and LIC between FerriScan® and dictionary-search analyses, suggesting generalizability of the R2-MRI approach for LIC estimation.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords