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Abstract #2599

Dynamic Monitoring of Liver Iron Overload and Chelation Therapy using Magnetic Resonance Imaging

Gregory Simchick1,2, Zhi Liu3, May Xiong3, and Qun Zhao1,2

1Physics and Astronomy, University of Georgia, Athens, GA, United States, 2Bio-Imaging Research Center, University of Georgia, Athens, GA, United States, 3Pharmaceutical & Biomedical Sciences, University of Georgia, Athens, GA, United States

Many diseases have been associated with excessive iron in the liver. Therefore, the non-invasive detection of liver iron overload and the monitoring of iron chelation therapy is highly desirable. Presented here is a method to demonstrate the feasibility of this using MR-based $$$R^{*}_{2}$$$ and magnetic susceptibility quantification. Significant increases in $$$R^{*}_{2}$$$ and susceptibility (Glass’ Δ values in the ranges of [-4.29 -3.23] and [-2.55 -2.23], respectively) are observed in iron overloaded livers in comparison to baseline measurements. After six doses of Polyrotaxane conjugated with Deferoxamine (rPR-DFO) iron chelation therapy administered over twelve days, Δ values of 0.13 and -0.09 are observed for $$$R^{*}_{2}$$$ and susceptibility, respectively, indicating that the differences are no longer significant and the treatment is effective.

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