Abstract #2601

Gradient-Echo MRI for Liver Iron Content Determination employing R2* Relaxometry: Influence of Gender and Disease

Arthur Peter Wunderlich^1,2, Sabrina Schweyer¹, Daniel Frisch¹, Justin Brosig¹, Holger Cario³, Meinrad Beer¹, and Stefan Andreas Schmidt¹

¹Diagnostic and Interventional Radiology, University Ulm, Medical Center, Ulm, Germany, ²Section for Experimental Radiology, University Ulm, Medical Center, Ulm, Germany, ³Department of Pediatrics and Adolescent Medicine, University Ulm, Medical Center, Ulm, Germany

To investigate the relation between R₂* gained from gradient echo (GRE) MRI and liver iron concentration (LIC), we studied the influence of patient characteristics. 205 patients (92 f, 113 m; 98 with Thalassemia major, 31 with Sickle Cell Anemia, 15 with Diamond-Blackfan-Anemia) suspected for liver iron overload were scanned according to Ferriscan^® with spin echo MRI to obtain reference LIC values, and GRE protocols suitable for LIC determination. GRE analysis based on manually drawn liver ROIs and relaxometry yielded R₂* values. Correlation analysis of R₂* to reference LIC revealed different correlation parameters between patient subgroups concerning disease and gender.

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