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Abstract #2602

Comparison of Hepatic Quantitative Susceptibility Mapping and R2* for Iron Measurement in Presence of Fat and Fibrosis; an Ex-Vivo Study

Ramin Jafari1, Anne Koehne de Gonzalez2, Yi Wang1,3, Thanh Nguyen 3, Alexey Dimov1, Kofi Mawuli Deh3, Zhe Liu1, Gary Brittenham2, Martin Prince3, and Pascal Spincemaille3

1Cornell University, Ithaca, NY, United States, 2Columbia University Medical Center, New York, NY, United States, 3Weill Cornell Medicine, New York, NY, United States

Precise measurement of liver iron content (LIC) in patients with transfusional iron overload is important in iron-chelation therapy. MRI can be used as a non-invasive method to measure iron levels in the liver. Typically, R2 and R2* based methods are used for this purpose. In this work, we use human liver explants to demonstrate the degree to which steatosis and fibrosis are confounding factors for R2* and quantitative susceptibility mapping in LIC measurement.

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