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Abstract #2603

Ultrashort Echo Time Imaging for Quantification of Hepatic Iron Overload: Comparison of Current Acquisition and Fitting Methods via Simulations and Phantom Data

Aaryani Tipirneni-Sajja1, Ralf B. Loeffler1, Andrea N. Sajewski1, Jane S. Hankins2, and Claudia M. Hillenbrand1

1Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, United States, 2Hematology, St. Jude Children's Research Hospital, Memphis, TN, United States

Assessment of hepatic iron content by R2*-MRI is a non-invasive alternative to liver biopsy. R2* is typically measured by a multiecho gradient-echo (GRE) sequence, however, GRE fails in high iron cases when T2* decay is rapid. In recent years, ultrashort echo time (UTE) imaging has been proposed to increase the accuracy in R2* measurements in high and massive iron overload. Still, the accuracy of R2* measurements depends on acquisition parameters and curve fitting algorithms, which vary between institutions. The purpose of this study is to compare current R2* acquisition and fitting methods, and identify the optimal acquisition and fitting methods for clinical use.

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