Meeting Banner
Abstract #2617

Diffusion MRI alteration following the induction of mild liver fibrosis in a rabbit model

Matteo Figini1, Liang Pan1,2, Chong Sun1,3, Bin Wang1,4, Junjie Shangguan1, Kang Zhou1,5, Na Shang1, Quanhong Ma1, and Zhuoli Zhang1

1Radiology, Northwestern University, Chicago, IL, United States, 2Radiology, The Third Affiliated Hospital of Soochow University, Changzhou, China, 3Orthopedics, Qilu Hospital, Shandong University, Jinan, China, 4General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China, 5Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

Nine rabbits were injected with carbon tetrachloride for 6 weeks to induce liver fibrosis. At the end of this period, these rabbits and 15 controls injected with saline underwent an imaging protocol including diffusion MRI. Histology showed mild fibrosis throughout the liver of the CCl4-injected animals. The Apparent Diffusion Coefficient in the liver of the fibrotic rabbits was significantly higher than in the controls. This counterintuitive result can be explained by the presence of many conflicting mechanisms during the early stage of fibrosis. If confirmed, the ADC could become a valuable tool for the early detection of liver fibrosis .

This abstract and the presentation materials are available to members only; a login is required.

Join Here