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Abstract #2618

Comprehensive analysis of advanced liver fibrosis in rats using multi-parameter MRI

Qing Li1, Shuangshuang Xie2, Hanxiong Qi2, Zhizheng Zhuo3, Yue Cheng2, and Wen Shen2

1Tianjin First Center Hospital, Tianjin, China, 2Radiology department, Tianjin First Center Hospital, Tianjin, China, 3Philips healthcare, Beijing China, Beijing, China

This study investigated the value of multi-parametric analysis using IVIM, DKI and MR T1ρ for the diagnosis of advanced liver fibrosis. Sixteen healthy rats and fifteen rats with advanced liver fibrosis (F4 confirmed by liver pathological examination) were scanned with IVIM, DKI and MR T1ρ. IVIM derived D*, D, f, DKI derived MD, K value and MR T1ρ derived T1ρ value were compared between the above two groups. Our results showed D*, D, f and MD decreased while K value and T1ρ value increased in rats with advanced liver fibrosis. And D*, D, f, K value and T1ρ value demonstrated significant difference (P<0.05). We therefore conclude that decreased D*, D and f and increased K value and T1ρ value could be useful in the diagnosis of liver fibrosis.

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