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Abstract #2619

Diagnostic value of intravoxel incoherent motion (IVIM) diffusion-weighted imaging in hepatic sinusoidal obstruction syndrome: an experimental study in a rat model – preliminary results

Eun Kyoung Hong1, Ijin Joo1, and Kyoungbun Lee2

1Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea, 2Department of Pathology, Seoul National University Hospital, Seoul, Republic of Korea

Hepatic sinusoidal obstruction syndrome (SOS), a toxic liver injury, needs an accurate diagnosis and serial monitoring for an effective management. Intravoxel incoherent motion (IVIM) DWI, which allows separate estimation of molecular diffusion and microcirculation, potentially provides information regarding hepatic parenchymal abnormalities. This study investigated the diagnostic value of IVIM-DWI in the assessment of hepatic SOS using a monocrotaline-induced rat SOS model. Our study results showed that ADC, true diffusion coefficient, and perfusion fraction showed significant correlation with the severity of SOS, which would suggest that IVIM-DWI may serve as a noninvasive method in the quantitative assessment of hepatic SOS.

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