Abstract #2623

Dynamic Contrast-Enhanced MRI to Assess Hepatocellular Carcinoma Response to Transarterial Chemoembolization: a Pilot Study.

Alana Thibodeau-Antonacci^1,2, Léonie Petitclerc^1,2, Guillaume Gilbert³, Laurent Bilodeau², Hélène Castel⁴, Simon Turcotte⁵, Damien Olivié², Catherine Huet², Pierre Perreault², Gilles Soulez², An Tang^1,2, and Samuel Kadoury^1,2,6

¹Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada, ²Radiology, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada, ³Philips Healthcare Canada, Markham, ON, Canada, ⁴Gastroentology and Hepatology, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada, ⁵Surgery, Hepatopancreatobiliary and Liver Transplantation Division, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada, ⁶Polytechnique Montréal, Montreal, QC, Canada

Hepatocellular carcinoma response to transarterial chemo-embolization is traditionally assessed by qualitative interpretation of imaging features and enhancement dynamics. However, quantitative parameters derived by fitting a dual-input single-compartment model on dynamic contrast-enhanced-MRI data show promise, as they may help discriminate non-viable from viable tumors after treatment. Peak enhancement ratio significantly decreased after transarterial chemo-embolization in tumors with complete response (i.e. non-viable tumor group). This pilot study suggests that quantitative dynamic contrast-enhanced-MRI parameters may be used to assess treatment response.

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