Abstract #2624

Dynamic contrast-enhanced MRI and intravoxel incoherent motion diffusion-weighted imaging for the evaluation of HCC response to 90Yttrium radioembolization

Stefanie Hectors¹, Paul Kennedy¹, Octavia Bane¹, Maxwell Segall¹, Sara Lewis^1,2, Myron Schwartz³, Edward Kim², and Bachir Taouli^1,2

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States

The goal of this study is to assess whether DCE-MRI and IVIM-DWI can be used to predict response of hepatocellular carcinoma (HCC) to 90Yttrium radioembolization (RE). In a preliminary cohort, significant changes were observed in both DCE-MRI and IVIM-DWI parameters at 6 weeks after treatment, which suggest that both techniques are sensitive to treatment effects of RE to HCC tissue. The exact utility of the DCE-MRI and IVIM-DWI parameters will be tested in a larger cohort.

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