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Abstract #2625

Estimating Liver Function by Gadoxetate Enhanced MRI: Comparison of Pharmacokinetic Models in a Clinical Setting

Markus Karlsson1, Gunnar Cedersund2, and Peter Lundberg1

1Department of Radiation Physics, and Department of Medical and Health Sciences and Center for Medical Image Science and Visualization (CMIV), Linköping Univeristy, Linköping, Sweden, 2Department of Biomedical Engineering, Linköping University, Linköping, Sweden

The hepatic uptake rate of Gadoxetate is a possible biomarker for liver function and several different pharmacokinetic models have been developed. However, no one has ever compared these models using the same data. We compared three different models using imaging data with low temporal, but high spatial resolution. We showed that two of the models estimates almost the same values of the hepatic uptake rate. The fact that two different pharmacokinetic models can produce the same parameter values validates the entire pharmacokinetic modelling approach, indicating that it is not just a model-specific parameter being estimated, but the actual transport rate.

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