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Abstract #2779

Synthetic MRI of the Knee: ISMRM/NIST Phantom Validation and In-Vivo Qualitative, Quantitative and Diagnostic Comparison with Conventional MRI of the Diagnosis of Internal Derangement

Neil Kumar1, Benjamin Fritz2, Steven Stern3, Marcel Warntjes4, Yen Mei Lisa Chuah5, and Jan Fritz1

1Radiology, Johns Hopkins Hospital, Baltimore, MD, United States, 2Balgrist University Hospital, Zurich, Switzerland, 3Bond Business School, Gold Coast, Australia, 4Center for Medical Imaging Science and Visualization (CMIV), Linköping University, Linköping, Sweden, 5Siemens Healthcare GmbH, Erlangen, Germany

Knee MRI protocols containing morphologic and quantitative pulse sequences allow comprehensive evaluation of multiple tissues. However, separate quantitative and qualitative image acquisitions are time consuming. We demonstrated excellent native and error-calibrated accuracy of synthetic MRI of the knee for T1, T2 and proton density quantification with use of an ISMRM/NIST phantom, and show excellent intra-day and inter-day repeatability in living human subjects. Synthetic MRI improves contrast-to-noise ratios of cartilage and menisci and yields improvements in artifact reduction and fat suppression. We demonstrate equivalent subjective ratings and diagnostic performance for internal derangement between conventional and synthetic MRI.

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