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Abstract #2828

Quantification of liver function by linearization of a 2-compartment model of gadoxetic-acid uptake using dynamic contrast enhanced magnetic resonance imaging

Josiah Simeth1,2, Adam Johansson2, Dawn Owen2, Kyle Cuneo2, Michelle Mierzwa2, Theodore Lawrence2, Mary Feng2,3, and Yue Cao1,2,4

1Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, 2Radiation Oncology, University of Michigan, Ann Arbor, MI, United States, 3Radiation Oncology, University of California San Francisco, San Francisco, CA, United States, 4Radiology, University of Michigan, Ann Arbor, MI, United States

This study used the uptake of gadoxetic acid contrast into the hepatocytes as a means of quantifying liver function. A linearized form of the dual-input two-compartment model was developed to estimate the uptake robustly and efficiently. Validation was obtained relative to the predictions of the accepted dual-input two-compartment model, and independent measurements of whole liver function. The linearized approach allows the creation of a spatially resolved quantitative image of liver function, using standard clinical acquisitions, and removes the requirement for impractical, high temporal resolution scans.

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