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Abstract #2829

Pseudo-CT generation from 3D multi-echo gradient-echo MRI

VĂ©ronique Fortier1,2 and Ives R. Levesque1,2,3

1Medical Physics Unit, McGill University, Montreal, QC, Canada, 2Biomedical Engineering, McGill University, Montreal, QC, Canada, 3Research Institute of the McGill University Health Centre, Montreal, QC, Canada

MRI-based treatment planning in radiotherapy is limited by the lack of electron density information and by the difficulty to differentiate air from bone regions. A completely automatic method to produce a pseudo-CT from a 3D gradient-echo dataset through voxel-wise assignment of computed tomography (CT) numbers (Hounsfield unit (HU)) was developed. The HU assignment is based on a combination of relative fat and water content and magnetic susceptibility estimates. The proposed method avoids registration errors and allows for HU variability in each tissue class. An improved quantitative susceptibility mapping algorithm for regions with large susceptibility and negligible signal is also presented.

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