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Abstract #2880

Towards a Routine Clinical Application of Chemical Exchange Sensitive MRI

Patrick Schuenke1, Ralf Omar Floca2,3, Caspar Jonas Goch2, Marco Nolden2, Moritz Zaiss4, Johannes Windschuh5, Hoai Nam Dang1, Christian David6, Volkert Roeloffs7, Peter Bachert1, and Mark E. Ladd1

1Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Division of Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany, 3Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany, 4Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 5Center for Biomedical Imaging, NYU Langone Medical Center, New York, NY, United States, 6Division of X-Ray Imaging and Computed Tomography, German Cancer Research Center (DKFZ), Heidelberg, Germany, 7Max Planck Institute for Biophysical Chemistry, Goettingen, Germany

Chemical exchange saturation transfer (CEST) and chemical exchange sensitive spinlock (CESL) were shown to have potential to provide molecular information for diagnosing a wide range of diseases. However, the lack of standardized acquisition protocols and freely available post-processing software prohibited the widespread application of these promising techniques until now. In this work, we present a modularly designed CEST/CESL preparation block that is easy to operate and can be used with arbitrary MRI readouts. Further, we developed and provide a C++ based open-source software that offers many CEST/CESL specific functionalities for the post-processing of the acquired data.

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