Abstract #2880

Towards a Routine Clinical Application of Chemical Exchange Sensitive MRI

Patrick Schuenke¹, Ralf Omar Floca^2,3, Caspar Jonas Goch², Marco Nolden², Moritz Zaiss⁴, Johannes Windschuh⁵, Hoai Nam Dang¹, Christian David⁶, Volkert Roeloffs⁷, Peter Bachert¹, and Mark E. Ladd¹

¹Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Division of Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany, ³Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany, ⁴Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ⁵Center for Biomedical Imaging, NYU Langone Medical Center, New York, NY, United States, ⁶Division of X-Ray Imaging and Computed Tomography, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁷Max Planck Institute for Biophysical Chemistry, Goettingen, Germany

Chemical exchange saturation transfer (CEST) and chemical exchange sensitive spinlock (CESL) were shown to have potential to provide molecular information for diagnosing a wide range of diseases. However, the lack of standardized acquisition protocols and freely available post-processing software prohibited the widespread application of these promising techniques until now. In this work, we present a modularly designed CEST/CESL preparation block that is easy to operate and can be used with arbitrary MRI readouts. Further, we developed and provide a C++ based open-source software that offers many CEST/CESL specific functionalities for the post-processing of the acquired data.

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