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Abstract #2898

Dynamic Nitroxide-Enhanced MRI Detects Oxidative Stress in Myocardial Infarction

Sophia Xinyuan Cui1, Soham A. Shah1, Christopher D. Waters1, Lanlin Chen1, Rene J. Roy2, Brent A. French1,2, and Frederick H. Epstein1,2

1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 2Radiology, University of Virginia, Charlottesville, VA, United States

Oxidative stress plays an important role in the pathogenesis of myocardial repair and remodeling after myocardial infarction (MI). Nitroxide free radicals have been used as redox-sensitive MRI contrasts agents in preclinical studies to assess tumor redox status. We tested the hypothesis that dynamic nitroxide-enhanced MRI can detect oxidative stress in MI. Imaging was performed in healthy control mice and in mice one day post-MI. The ratio of the MRI signal decay between the infarcted anterolateral wall and the noninfarcted septum was significantly higher in mice after MI, indicating that nitroxide-enhanced MRI can detect increased oxidative stress in infarcted myocardium.

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