Cardiac late gadolinium enhancement (LGE) imaging has become a reference clinical tool for assessing myocardial scar and viability. Despite superior signal-to-noise-ratio of 3D LGE techniques, current 3D breath-hold acquisitions are still limited by scan time and low-resolution, especially in the through-plane direction. Consequently, most clinical protocols include three anisotropic LGE acquisitions in different views to better visualize myocardial fibrosis in different orientations. Nevertheless, assessing myocardial viability in different views remains tedious and time-consuming. In this study, we sought to achieve isotropic 3D LGE by combining low-resolution anisotropic acquisitions using a 3D patch-based super-resolution reconstruction.
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