Abstract #2900

Cardiac relaxometry in childhood acute lymphoblastic leukemia survivors.

Delphine Perie-Curnier¹, Mohamed Aissiou¹, Louise Leleu¹, Farida Cheriet², Tarik Hafyane³, Maja Krajinovic⁴, Caroline Laverdiere⁴, Daniel Sinnett⁴, Gregor Andelfinger⁴, and Daniel Curnier⁵

¹Mechanical Engineering, Polytechnique Montreal, Montreal, QC, Canada, ²Computing and software engineering, Polytechnique Montreal, Montreal, QC, Canada, ³Research Center, Montreal Heart Institute, Montreal, QC, Canada, ⁴Research Center, CHU Sainte-Justine, Montreal, QC, Canada, ⁵Kinesiology, University of Montreal, Montreal, QC, Canada

The aim of this study was to evaluate T1 pre- and post-gadolinium enhancement and T2 relaxation times sensitivity to detect myocardial changes induced by doxorubicin-based chemotherapy in childhood acute lymphoblastic leukemia survivors. Myocardial changes such as increased fibrosis index and injury due to associated changes in myocardial free water content were found between risk groups of cancer survivors, suggesting T2, post-gadolinium T1 and particularly the partition coefficient as early indices for myocardial tissue damages in the onset of doxorubicin-induced cardiotoxicity. These computing tools will be pivotal in patient follow-up to anticipate pathology evolution.

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