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Abstract #2901

Age, gender and heart rate dependency of spin echo based diffusion tensor imaging measurements in healthy hearts

Alexander Gotschy1,2, Constantin von Deuster1, Robbert J.H. van Gorkum1, Ella Vintschger1, Robert Manka2,3, Christian T. Stoeck1, and Sebastian Kozerke1

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2Department of Cardiology, University Hospital Zurich, Zurich, Switzerland, 3Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland

Cardiac diffusion tensor imaging (cDTI) is a novel non-invasive method that allows assessing changes in myocardial microstructure in various cardiomyopathies. To identify pathologies, however, the distribution of cDTI parameters and their subject specific dependencies in normal hearts need to be known. Therefore, we investigated age, gender and heart rate dependencies of quantitative parameters derived from spin-echo based cDTI in healthy subjects. Our results display the variation of cDTI parameters in normal hearts and thereby allow gauging at which level of expected pathological changes sex and age matched reference values will be needed in future clinical practice.

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