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Abstract #2909

Assessing myocardial infarct in lymphatic insufficient mice by rotating frame relaxation times

Elias Yla-Herttuala1, Taina Vuorio1, Johanna Laakkonen1, Svetlana Laidinen1, Seppo Yla-Herttuala1, and Timo Liimatainen1,2

1A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland, 2Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland

Relaxation times T2, T and RAFFn were applied to study alterations in myocardial infarct (MI) in control and in mice with insufficient lymphatic system (VEGFR3). The findings are supported by cardiac functional parameters and histology. We found significant difference between VEGFR3 and control in TRAFF4 (p<0.05) 8 days after MI and between pre-MI and post-MI time points in T2 (p<0.01). Relaxation times increased significantly (p<0.05) after MI in all measurements. We conclude that TRAFF4 gain information of alterations of fibrosis in lymphatic insufficiency after MI.

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