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Abstract #2911

Multi-Parametric Cardiac MRI is Needed for Accurate Staging of Reperfused Hemorrhagic Myocardial Infarctions

Guan Wang1,2, Hsin-Jung Yang1, Ivan Cokic1, Avinash Kali1, Richard Tang1, Joseph Francis3, Songbai Li2, and Rohan Dharmakumar1,4

1Pacific Theatres Suite 400. 8700 Bevely Boulevard, Cedars-Sinai Medical Center BIRI, Los angeles, CA, United States, 2Dept of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China, 3Dept of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, Baton Rouge, LA, United States, 4David Geffen School of Medicine, University of California, Los angeles, CA, United States

Cardiac MRI (CMR) based staging of myocardial infarction (MI) with or without contrast agents relies on the resolution of edema in the chronic phase, which is typically determined on the basis of T2-based MRI. However, whether T2 CMR is sufficient for staging all MI types has not been studied. We investigated this using animal models with and without hemorrhagic MIs. Our results show that non-hemorrhagic MIs can be staged based on T2 changes in the MI territory. However, the incomplete resolution of T2 elevations in the peripheral layers of hemorrhagic MI territories can confound staging of hemorrhagic MIs.

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