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Abstract #2956

Protective effect of Resveratrol against cardiac dysfunction and impaired energy metabolism of type 2 diabetic female GK rat heart submitted to Ischemia-Reperfusion injury

Natacha Fourny1, Carole Lan1, Eric Sérée2, Laurent Pechere3, Monique Bernard1, and Martine Desrois1

1Aix Marseille Univ, CNRS, CRMBM, Marseille, France, 2Aix-Marseille Univ, UMR Inserm 1062/ INRA 1260, NORT, Marseille, France, 3YVERY sarl, Marseille, France

Type 2 diabetes doubles the risk of myocardial infarction in women. New treatments need to be found to reduce cardiovascular mortality. Consequently, we investigated the effect of Resveratrol (RSV) on the tolerance to ischemia-reperfusion (IR) injury of type 2 diabetic female Goto-Kakizaki (GK) rat heart. We used a multiparametric approach allowing simultaneous measurement of cardiac function, energy metabolism by 31P MRS and endothelial function. Oral RSV treatment improved myocardial performance, coronary flow and energy metabolism during reperfusion in GK rats. Consequently, RSV might be an interesting therapeutic approach to improve survival to myocardial IR injury of type 2 diabetic women.

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