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Abstract #2957

Longitudinal follow-up of endothelial function after ischemia reperfusion injury treated with a novel regenerative therapy by albumin-based DCE MRI

Maaike van den Boomen1, Patricia Y.W. Dankers2,3,4, Leonie B.P. Niesen1, Carlijn V.C. Bouten2, and Katrien Vandoorne1

1Biomedical Engineering, Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands, 2Biomedical Engineering, Soft Tissue Biomechanics & Tissue Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 3Institute for Complex Molecular Systems, Eindhoven, Netherlands, 4Biomedical Engineering, Organic Chemistry, Eindhoven University of Technology, Eindhoven, Netherlands

Dynamic contrast enhanced (DCE) MRI in combination with gadolinium-labeled albumin enabled longitudinal follow up of a novel hydrogel based regenerative therapy to treat myocardial infarction (MI). The local fractional blood volumes (fBVa measure for microvascular density) and permeability surface areas in the myocardium were increased at day 3 after MI due to the growth factors released from the hydrogel. This increase might indicate angiogenesis, which improves the inflammatory response. At day 7 the vascular density and permeability went back to normal again, which possibly avoid excessive extension of the MI.

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