Abstract #3009

Differentiation of blood clot hematocrit and age in vitro using R2* and quantitative susceptibility mapping at 3T

Spencer D Christiansen^1,2, Junmin Liu¹, Joy Dunmore-Buyze¹, Michael B Boffa³, and Maria Drangova^1,2

¹Imaging Research Laboratories, Robarts Research Institute, Western University, London, ON, Canada, London, ON, Canada, ²Dept. of Medical Biophysics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada, London, ON, Canada, ³Dept. of Biochemistry, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada, London, ON, Canada

Thrombus composition and age in ischemic occlusion can significantly influence treatment efficacy, yet current MR characterization methods are qualitative and cannot distinguish between the effects of red blood cell age and concentration (hematocrit). We examined the ability of R₂* and quantitative susceptibility (QS) maps derived simultaneously from multi-echo GRE acquisition to discriminate between blood clots of varied hematocrit formed in vitro and monitored over a six-day ageing period. Fresh clots (age < 6 hours) of different hematocrit were distinguishable using either R₂* or QS values, while aged clots were distinguishable only when both values were considered.

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