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Abstract #3021

Investigating the relationship between perfusion and glucose metabolism by simultaneous PET/MRI in frontotemporal dementia.

Rebecca M.E. Steketee1, Mariachiara Longarzo2, Vincenzo Alfano2, Carlo Cavaliere2, Dario Grossi3, Marion Smits1, and Marco Aiello2

1Radiology & Nuclear Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, Netherlands, 2NAPLAB - SDN NeuroAnatomy and image Processing LABoratory, IRCCS SDN, Naples, Italy, 3Department of Psychology, University of Campania Luigi Vanvitelli, Caserta, Italy

Arterial spin labeling (ASL)-magnetic resonance imaging (MRI) and fluorodeoxyglucose (FDG)-positron emission tomography (PET) both have diagnostic value for dementia, particularly frontotemporal dementia (FTD). By using simultaneous FDG-PET/ASL-MRI, we investigated the relationship between brain metabolism and perfusion in FTD, to evaluate their suitability and complementarity. Exploratory analysis of simultaneous FDG-PET/ASL-MRI in 15 dementia patients showed that metabolism and CBF correlate well on a global level, both visually and quantitatively. On a regional level, one-on-one correlations are limited, supposedly to disease-specific regions such as frontotemporal, subcortical and parietal regions. These results will be substantiated in a larger and better differentiated dementia cohort.

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