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Abstract #3031

Neurovascular coupling to D2/D3 partial agonist antipsychotic drug occupancy using simultaneous PET/fMRI

Christin Y Sander1,2, Bruce R Rosen1,2, and Joseph B Mandeville1,2

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 2Harvard Medical School, Boston, MA, United States

Drug-receptor interactions are the basis of signal modulation in the brain, yet, in vivo mechanisms of the action of many drugs are not well understood. In this study, we characterize the in vivo profile of a current third generation antipsychotic drug at the D2/D3 dopamine receptor using simultaneous PET and fMRI. The results are compared to full D2/D3 antagonists and agonists profiles and show that functional differences can be distinguished with occupancy-matched fMRI responses.

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