Drug-receptor interactions are the basis of signal modulation in the brain, yet, in vivo mechanisms of the action of many drugs are not well understood. In this study, we characterize the in vivo profile of a current third generation antipsychotic drug at the D2/D3 dopamine receptor using simultaneous PET and fMRI. The results are compared to full D2/D3 antagonists and agonists profiles and show that functional differences can be distinguished with occupancy-matched fMRI responses.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords