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Abstract #3032

Feasibility study of multinuclear MR at 9.4T and PET in a rat brain tumour model

Chang-Hoon Choi1, Carina Stegmayr1, Aliaksandra Shymanskaya1, Wieland A. Worthoff1, Nuno A da Silva1, Jörg Felder1, Karl-Josef Langen1,2, and N. Jon Shah1,3

1Forschungszentrum Juelich, Juelich, Germany, 2Department of Nuclear Medicine and Neurology, RWTH Aachen University Hospital, Aachen, Germany, 3Faculty of Medicine, Department of Neurology, RWTH Aachen University, JARA, Aachen, Germany

Multinuclear MR provides important information concerning cell integrity or energy metabolism. PET uses radioactive tracers to gain valuable insights into physiological and metabolic processes with both a high level of sensitivity and specificity. Here, we explored the combination of sequential multinuclear MR and PET in a rat brain tumour model. This allows in vivo multinuclear MR-PET experiments to be carried out without compromising the performance of either multinuclear MR or PET. In vivo multinuclear MR and PET images and spectra from rats with/without brain tumours confirmed the potential use of the different X-nuclei derived metabolic information.

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