Here we show the ability of using Gadolinium (Gd) labeled thermosensitive liposomal nanoparticle (TSLnp) as a delivery system for anticancer drug, gemcitabine (Gem) to human pancreatic tumors. Pancreatic cancer (PCa) due to its high malignancy, poor prognosis and resistance to chemotherapy is one of the leading cancer-associated death in the United States. The proposed agent showed significant Gem accumulation in heated tumor relative to free Gem. Gd labeled TSLnp (Gd-TSLnp) show contrast in ex vivo tumor tissue. The Gd-TSLnp show increased T1 contrast in vivo with an implanted tumor compared to Gd and targets the tumor tissue.