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Abstract #3034

Benzene-Appended Cucurbit[6]uril as a Potential Biosensor Scaffold for Hyperpolarized 129Xe MRI Molecular Contrast Agents

Braedan R. J. Prete1, Dave Robinson2, Ashvin Fernando2, Yurii Shepelytskyi1, Alanna Wade1, Francis T. Hane1,3, Brenton DeBoef2, and Mitchell S. Albert1,3,4

1Chemistry, Lakehead University, Thunder Bay, ON, Canada, 2Chemistry, University of Rhode Island, Kingston, RI, United States, 3Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada, 4Biology, Northern Ontario School of Medicine, Thunder Bay, ON, Canada

We have recently advanced the field of hyperpolarized (HP) 129Xe magnetic resonance imaging (MRI) with the in vivo detection of cucurbit[6]uril (CB6), a highly sensitive MR contrast agent. CB6 is biochemically inactive, which makes its natural bio-distribution non-specific; thus, it cannot be precisely localized within a living mammalian body using HP 129Xe MRI. We have previously identified cyclodextrin-based pseudorotaxanes as conjugatable scaffolds for xenon biosensors; in this work, we introduce a second class of conjugatable scaffolds, with the hyperCEST detection of benzene-appended CB6, a potential precursor to a wide variety of targeted molecular imaging probes.

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