Abstract #3035

Prospects of 31P Contrast Media for 31P-MRS

Louise R. Tear^1,2, Mahon L. Maguire², Gogulan Karunanithy³, Deborah Sneddon⁴, Nicola J. Farrer¹, Andrew Baldwin³, Stephen Faulkner¹, and Jurgen E. Schneider^2,5

¹Chemistry Research Laboratory, University of Oxford, Oxford, United Kingdom, ²BHF Experimental MR Unit (BMRU), University of Oxford, Oxford, United Kingdom, ³Physical and Theoretical Chemistry Laboratory, University of Oxford, Oxford, United Kingdom, ⁴Radiobiology Research Institute, University of Oxford, Oxford, United Kingdom, ⁵Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom

³¹P-MRS can be used to determine the relative ratios of phosphate species in vivo to aid clinical diagnosis, but is limited by poor SNR and long acquisition times associated with the ³¹P nucleus. This work investigates the potential of ³¹P T₁ contrast agents based on Gd.DO3A derivatives by using ³¹P-MRS. These compounds demonstrate significant relaxation enhancement of ³¹P R₁ for ATP, PCr and P_i, therefore showing excellent potential as ³¹P contrast agents. Cell studies indicate the Gd.DO3A derivatives investigated do not come into contact with intracellular phosphate metabolites, which limits these initial complexes to use as extracellular contrast agents.

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