Abstract #3036

Dysprosium based liver-specific ultra-high field MRI T2 contrast agent

Ah Rum Baek¹, Heekyung Kim^2,3, Soyeon Kim¹, Garam Choi¹, Bokyung Sung¹, MD. Kamrul Islam¹, Taekwan Lee⁴, DongKyu Kim⁴, Hoesu jung⁴, and Yongmin Chang^1,2,5

¹Department of Medical &Biological Engineering, Kyungpook National Univesity, Daegu, Korea, Democratic People's Republic of, ²Department of Molecular Medicine & BK21 Plus KNU Biomedical Convergence Program, Kyungpook National Univesity, Daegu, Korea, Democratic People's Republic of, ³Institute of Biomedical Engineering Research, Kyungpook National University, Daegu, Korea, Democratic People's Republic of, ⁴Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Korea, Democratic People's Republic of, ⁵Department of Radiology, Kyungpook National Univesity, Daegu, Korea, Democratic People's Republic of

[Dy(EOB-DO3A)] is prepared according to the general synthetic methods, and characterized by spectroscopic analysis.Therelaxivities that measured at 9.4 T animal MRI are r₁ = 1.01, r₂ = 2.80 mM^-1s^-1.We observe acceptablenegative-enhancement with liver T₂-weighted image, alsoconfirm about 30% liver accumulation within 1 h post-injection at inductively coupled plasma (ICP) spectrometer data.

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