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Abstract #3039

A Small Molecule NIR-19F MR Contrast Agent of Aza-BODIPY for Bimodal In Vivo Imaging

Lianhua Liu1, Yaping Yuan1, Yuqi Yang1, McMahon T. Michael 2,3, Shizhen Chen1, and Xin Zhou1

1State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Wuhan, China, 2Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Accurate and early diagnosis of diseases is most import for medical imaging. MRI is one of the most promising techniques for the non-invasive visualization. Compared to 1H MRI, 19F MRI provides high-contrast images without endogenous background signals, but low sensitivity. To address the limitation, our strategy is to combination of 19F MRI and a more sensitive NIR fluorescence imaging technique to develop a bimodal contrast agent BDPF. Both ex vivo and in vivo experimental results indicated BDPF had excellent optical and 19F MRI properties. Thus, the NIR-19F MR bimodal imaging may provide a new way to detect tumor.

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