Abstract #3040

Manganese enhanced MRI in organotypic rat hippocampus slices: A correlative study with synchrotron X-ray nanoprobe analysis and electron microscopy.

Alexia Daoust¹, Natalia B Pivovarova¹, Emily Petrus¹, S Brian Andrews¹, Barry Lai², Si Chen², Maria A Aronova³, Richard D Leapman³, and Alan P Koretsky¹

¹National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, ²Argonne National Laboratory, Advanced Photon Source, Argonne, IL, United States, ³National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, United States

Manganese (Mn2+) Enhanced Magnetic Resonance Imaging (MEMRI) can be used for different applications such as tracing neuronal connections or functional imaging. However, Mn²⁺ uptake and transport mechanisms are still unclear. These mechanisms were studied by imaging sub-cellular Mn2+ in an organotypic hippocampal slice culture by coupling MEMRI, TEM and X-ray methodologies. The data indicates that Mn²⁺ is located at synapses but not in mitochondria.

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