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Abstract #3057

Impurities of [1-¹³C]pyruvic acid and their potential effects on the interpretation of hyperpolarized pyruvate metabolism studies

Talia Harris1, Ayelet Gamliel1, Jacob Sosna1, J. Moshe Gomori1, and Rachel Katz-Brull1

1Hadassah-Hebrew University Medical Center, Jerusalem, Israel

Commercially available [1-13C]pyruvic acid contains impurities that have chemical shifts similar to pyruvate’s metabolic products. We show that these observed impurity peaks possess long T1s and for several peaks the chemical shift is very sensitive to the pH in the narrow physiological range measured. We concluded that in order to reliably identify low concentration metabolic products of hyperpolarized pyruvate it is crucial to characterize in situ the pH dependent impurity spectrum of the batch of [1-13C]pyruvic acid used.

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