Meeting Banner
Abstract #3056

Ex-vivo real-time measurement of ethanol induced changes in brain metabolism of hyperpolarized [1-13C]-pyruvate

Benjamin Grieb1, Assad Azar1, Talia Harris1, Gal Sapir1, Atara Nardi-Schreiber1, Ayelet Gamliel1, Sivaranjan Uppala1, Jacob Sosna1, J. Moshe Gomori1, and Rachel Katz-Brull1

1Department of Radiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

Changes in brain metabolism during acute alcohol intoxication either reflect global inhibition or changes in the utilized energy substrates. NMR spectroscopy of hyperpolarized metabolites offer the opportunity to investigate the metabolic changes due to alcohol intoxication in the brain in real time. Here we present preliminary data showing decreased [1-13C]lactate formation from hyperpolarized [1-13C]pyruvate in perfused and ethanol incubated rat brain slices. This approach may offer a future innovative tool to non-invasively image brain metabolism in real-time during alcohol intoxication.

This abstract and the presentation materials are available to members only; a login is required.

Join Here