Changes in brain metabolism during acute alcohol intoxication either reflect global inhibition or changes in the utilized energy substrates. NMR spectroscopy of hyperpolarized metabolites offer the opportunity to investigate the metabolic changes due to alcohol intoxication in the brain in real time. Here we present preliminary data showing decreased [1-13C]lactate formation from hyperpolarized [1-13C]pyruvate in perfused and ethanol incubated rat brain slices. This approach may offer a future innovative tool to non-invasively image brain metabolism in real-time during alcohol intoxication.
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