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Abstract #3055

Simple and fast hyperpolarization of a biomolecule: Theory and Experiment

Stephan Berner1,2,3, Stephan Knecht1,4, Andreas Benjamin Schmidt1,4, Mirko Zimmermann1, Jürgen Hennig1, Dominik von Elverfeldt1, and Jan-Bernd Hövener4

1Department of Radiology, Medical Physics, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 2DKTK, Freiburg, Germany, 3DKFZ, Heidelberg, Germany, 4Department of Radiology and Neuroradiology, Section Biomedical Imaging, MOIN CC University Medical Center Schleswig-Holstein, University of Kiel, Kiel, Germany

Hyperpolarization overcomes the biggest limitation of MRI: its low sensitivity, and enables metabolite mapping. Hyperpolarized 13C magnetization can be produced by transferring the spin order of parahydrogen into 13C by hydrogenation followed by a sequence of 1H and 13C pulses. However, it is possible to hyperpolarize AA’X spin systems by two pulses on 13C. Theoretical models were developed to describe the polarization transfer and significant signal increase was observed for the biomolecule succinate after spin order transfer directly in the magnet of a commercial MRI system. The experimental data is well described by theoretical calculations except for an overall scaling factor.

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