Meeting Banner
Abstract #3054

Dynamic Metabolic Imaging of Co-Polarized [2-13C]Pyruvate and [1,4-13C2]Fumarate Using 3D-Spiral CSI with Alternate Spectral Band Excitation

Maninder Singh1, Sonal Josan2, and Dirk Mayer1

1Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD, United States, 2Siemens Healthcare, Erlangen, Germany

Metabolic imaging of biologically-relevant hyperpolarized agents allows measurement of metabolic processes in real time in-vivo. We demonstrate dynamic metabolic imaging of a single bolus of co-polarized [2-13C]pyruvate and [1,4-13C2]fumarate in control as well as in rats with liver necrosis. Chemical shift imaging (CSI) of such a mixture is challenging due to the large spectral dispersion of resulting resonances, which could lead to severe chemical shift displacement artifacts if acquired by conventional slice-selective excitation pulses. Here we obtain CSI information by a volumetric method using alternate 3D spectrally-selective excitation of sub-bands containing fewer resonances.

This abstract and the presentation materials are available to members only; a login is required.

Join Here