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Abstract #3059

In vivo hyperpolarization transfer in a clinical MRI scanner

Cornelius von Morze1, Galen D. Reed2, Peder E. Larson1, Daniele Mammoli1, Albert P. Chen2, James Tropp3, Mark Van Criekinge1, Michael A. Ohliger1, John Kurhanewicz1, Daniel B. Vigneron1, and Matthew E. Merritt4

1Department of Radiology & Biomedical Imaging, UCSF, San Francisco, CA, United States, 2GE Healthcare, San Francisco, CA, United States, 3Berkshire Magnetics, Berkeley, CA, United States, 4Department of Biochemistry, University of Florida, Gainesville, Gainesville, FL, United States

The purpose of this study was to investigate the feasibility of in vivo 13C->1H hyperpolarization transfer, which has significant potential advantages for detecting the distribution and metabolism of hyperpolarized 13C probes, in a clinical MRI scanner. A standalone pulsed 13C RF transmit channel was developed for operation in conjunction with the standard 1H channel of a clinical 3T MRI scanner. Operation of the custom pulsed 13C RF channel resulted in effective 13C->1H hyperpolarization transfer, as confirmed by the characteristic anti-phase appearance of 1H-detected, 1JCH-coupled doublets. 1H detection of HP [2-13C]lactate generated in vivo was achieved in a rat liver slice.

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