The serine synthesis pathway (SSP), which provides precursors for redox homeostasis and nucleotide synthesis, has emerged as a critical metabolic pathway in cancer. However, the assessment of therapeutic approaches targeting the SSP has been challenging due to a lack of distinct biomarkers. We have identified that the SSP inhibition increases reactive oxygen species (ROS) levels and, intriguingly, glycolytic rate in leukemia cells. Using hyperpolarized dehydroascorbate and pyruvate magnetic resonance, we assessed therapeutic responses earlier than any significant changes in cell viability. This approach has broad implications as an effective methodology for monitoring therapeutic responses with SSP inhibition in multiple cancers.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords