Abstract #3061

In vitro and in vivo 13C metabolic imaging of pyruvate to lactate conversion with high spatial and temporal resolution using a me-bSSFP sequence

Christoph Alexander Müller^1,2, Christian Hundshammer³, Miriam Braeuer³, Jason Graham Skinner¹, Adam Espe Hansen⁴, Sven Mansson⁵, Franz Schilling³, Jochen Leupold¹, Dominik von Elverfeldt¹, Jan Henrik Ardenkjaer-Larsen⁶, Markus Schwaiger³, Jürgen Hennig¹, and Jan-Bernd Hövener⁷

¹Department of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, ²German Consortium for Translational Cancer Research (DKTK), Partnersite Freiburg, German Center for Cancer Research (DKFZ), Heidelberg, Germany, ³Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, München, Germany, ⁴Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, ⁵Medical Radiation Physics, Malmö University Hospital, Lund University, Malmö, Sweden, ⁶Department of Electrical Engineering, Technical University of Denmark, Copenhagen, Denmark, ⁷Section for Biomedical Imaging, Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein, University of Kiel, Kiel, Germany

In order to use the transient signal of hyperpolarized tracers and their metabolites efficiently, dedicated imaging sequences are required. Here, we present a multi-echo bSSFP sequence with Dixon-based iterative reconstruction to obtain metabolite maps of hyperpolarized [1‑¹³C]pyruvate and the product of an enzymatic conversion [1-¹³C]lactate on a human 3T PET-MRI system in vitro and in vivo. When comparing to other methods (i.e. CSI and non-localized NMR spectra) we found that me-bSSFP provides good metabolite separation and reliable quantitative kinetic data more than 16 times faster than CSI (350 ms vs. 5.8 s), while consuming a similar amount of hyperpolarized magnetization.

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