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Abstract #3062

In Vivo Spectroscopic Detection of Arginase Enzyme Activity with Hyperpolarized [6-13C,15N3]-Arginine

Andrew Cho1, Roozbeh Eskandari2, and Kayvan Keshari2

1Weill Cornell Graduate School, New York, NY, United States, 2Memorial Sloan Kettering Cancer Center, New York, NY, United States

Aberrations in arginase enzyme expression are associated with a variety of pathologies, and an in vivo probe to quantify flux through this pathway may hold utility towards patient stratification. We propose the use our custom synthesized compound, [6-13C,15N3]-arginine, as a hyperpolarized MRI probe for arginase activity. 15N enrichment reduces quadrupolar relaxation and extends T2, facilitating in vivo imaging. We were able to acquire 13C spectroscopic data on a healthy mouse and detected in vivo conversion of hyperpolarized arginine to urea, which warrants further exploration of this imaging probe in the future.

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