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Abstract #3063

Recent advances in low-cost, rapid Hyperpolarization Chemistry: from portable NMR to low-cost molecular MRI.

Thomas Theis1, Johannes Colell1, Zijian Zhou1, Shannon Eriksson2, Jacob Lindale1, Yi-Fen Yen3, Matthew Rosen3,4, Eduard Chekmenev5, and Warren Warren6

1Chemistry, Duke University, Durham, NC, United States, 2Medicine, Duke University, Durham, NC, United States, 3A. A. Martinos Center for Biomedical Imaging, Massachsetts General Hospital, Charlestown, MA, United States, 4Physics, Harvard University, Cambridge, MA, United States, 5Vanderbilt Univesity Institute for Imaging Science, Nashville, TN, United States, 6Physics, Chemistry, BME, Radiology, Duke University, Durham, NC, United States

NMR and MRI are inherently low sensitivity techniques. Hyperpolarization technology overcomes this problem by enhancing MR signals by 10,000-fold or more. However, most hyperpolarization techniques are complex, expensive and slow. We describe hyperpolarization chemistry that is simple, low-cost, and fast or even continuous. Specifically, we describe recent advances in parahydrogen-induced polarization, combined with various MR detection schemes to establish 1) miniaturized NMR spectrometers, 2) NMR structural elucidation with reduced limits of detection, and 3) low-cost biomolecular imaging.

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