Abstract #3063

Recent advances in low-cost, rapid Hyperpolarization Chemistry: from portable NMR to low-cost molecular MRI.

Thomas Theis¹, Johannes Colell¹, Zijian Zhou¹, Shannon Eriksson², Jacob Lindale¹, Yi-Fen Yen³, Matthew Rosen^3,4, Eduard Chekmenev⁵, and Warren Warren⁶

¹Chemistry, Duke University, Durham, NC, United States, ²Medicine, Duke University, Durham, NC, United States, ³A. A. Martinos Center for Biomedical Imaging, Massachsetts General Hospital, Charlestown, MA, United States, ⁴Physics, Harvard University, Cambridge, MA, United States, ⁵Vanderbilt Univesity Institute for Imaging Science, Nashville, TN, United States, ⁶Physics, Chemistry, BME, Radiology, Duke University, Durham, NC, United States

NMR and MRI are inherently low sensitivity techniques. Hyperpolarization technology overcomes this problem by enhancing MR signals by 10,000-fold or more. However, most hyperpolarization techniques are complex, expensive and slow. We describe hyperpolarization chemistry that is simple, low-cost, and fast or even continuous. Specifically, we describe recent advances in parahydrogen-induced polarization, combined with various MR detection schemes to establish 1) miniaturized NMR spectrometers, 2) NMR structural elucidation with reduced limits of detection, and 3) low-cost biomolecular imaging.

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