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Abstract #3064

Boosting SABRE-SHEATH hyperpolarization with Coherent Control of Spin Dynamics

Thomas Theis1, Shannon Eriksson1, Johannes Colell1, Zijian Zhou1, Jacob Lindale1, and Warren Warren2

1Chemistry, Duke University, Durham, NC, United States, 2Physics, Chemistry, BME, Radiology, Duke University, Durham, NC, United States

Signal Amplification By Reversible Exchange (SABRE) is a parahydrogen based hyperpolarization modality that is particularly simple, low-cost, and fast or even continuous. A more recent variant, SABRE-SHEATH (SABRE in SHield Enables Alignment Transfer to Heteronuclei) enables targeting 15N and 13C nuclei in a wide range of substrates, where hyperpolarization lifetimes can be particularly long. However, both SABRE and SABRE-SHEATH are limited by the incoherent nature of the hyperpolarization transfer process. Here we describe a pulsed variant of SABRE-SHEATH that takes coherent control over the spin dynamics and more than doubles achievable hyperpolarization levels. In addition, the pulsed SABRE-SHEATH experiments provide a new way of probing the hyperpolarization transfer, shedding new light on the limiting factors of this emerging technology.

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