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Abstract #3077

Feasibility and benefits of 3-tissue constrained spherical deconvolution for studying the brains of babies

Thijs Dhollander1, Julien Zanin2,3, Bryony A. Nayagam2, Gary Rance2,3, and Alan Connelly1,4

1The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, 2Department of Audiology and Speech Pathology, University of Melbourne, Melbourne, Australia, 3The HEARing Cooperative Research Centre, Melbourne, Australia, 4The Florey Department of Neuroscience, University of Melbourne, Melbourne, Australia

When studying white matter in baby brains with diffusion-weighted imaging, we face a range of challenges, including larger water-content, lower anisotropy, differentiated maturation and a (relatively) larger proportion of the brain being comprised of grey matter. We attempt to apply single-tissue, 2-tissue and 3-tissue constrained spherical deconvolution (CSD) to single-shell data of two 5 month old babies. 3-tissue CSD still worked successfully. The nature of benefits was in line with those obtained previously in adults, but they were greater in the babies, mostly due to a much larger presence of GM-like tissue.

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