Abstract #3077

Feasibility and benefits of 3-tissue constrained spherical deconvolution for studying the brains of babies

Thijs Dhollander¹, Julien Zanin^2,3, Bryony A. Nayagam², Gary Rance^2,3, and Alan Connelly^1,4

¹The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, ²Department of Audiology and Speech Pathology, University of Melbourne, Melbourne, Australia, ³The HEARing Cooperative Research Centre, Melbourne, Australia, ⁴The Florey Department of Neuroscience, University of Melbourne, Melbourne, Australia

When studying white matter in baby brains with diffusion-weighted imaging, we face a range of challenges, including larger water-content, lower anisotropy, differentiated maturation and a (relatively) larger proportion of the brain being comprised of grey matter. We attempt to apply single-tissue, 2-tissue and 3-tissue constrained spherical deconvolution (CSD) to single-shell data of two 5 month old babies. 3-tissue CSD still worked successfully. The nature of benefits was in line with those obtained previously in adults, but they were greater in the babies, mostly due to a much larger presence of GM-like tissue.

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